Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4958733..4959328 Replicon chromosome
Accession NZ_CP122768
Organism Escherichia coli strain ETEC1738

Toxin (Protein)


Gene name chpB Uniprot ID -
Locus tag QDY55_RS24805 Protein ID WP_064225787.1
Coordinates 4958733..4959083 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag QDY55_RS24810 Protein ID WP_001223213.1
Coordinates 4959077..4959328 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY55_RS24785 (4954187) 4954187..4955209 - 1023 WP_001298067.1 ABC transporter permease -
QDY55_RS24790 (4955223) 4955223..4956725 - 1503 WP_064225788.1 sugar ABC transporter ATP-binding protein -
QDY55_RS24795 (4956858) 4956858..4957814 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
QDY55_RS24800 (4958124) 4958124..4958654 + 531 WP_000055075.1 inorganic diphosphatase -
QDY55_RS24805 (4958733) 4958733..4959083 - 351 WP_064225787.1 endoribonuclease toxin ChpB Toxin
QDY55_RS24810 (4959077) 4959077..4959328 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
QDY55_RS24815 (4959540) 4959540..4959881 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
QDY55_RS24820 (4959884) 4959884..4963663 - 3780 WP_149448756.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-115)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12481.46 Da        Isoelectric Point: 6.2206

>T277881 WP_064225787.1 NZ_CP122768:c4959083-4958733 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYVGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT277881 WP_001223213.1 NZ_CP122768:c4959328-4959077 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References