Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4947262..4947784 Replicon chromosome
Accession NZ_CP122768
Organism Escherichia coli strain ETEC1738

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag QDY55_RS24745 Protein ID WP_001105433.1
Coordinates 4947262..4947552 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2S8JQB3
Locus tag QDY55_RS24750 Protein ID WP_064225789.1
Coordinates 4947542..4947784 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY55_RS24730 (4942425) 4942425..4944080 + 1656 WP_064225790.1 alpha,alpha-phosphotrehalase -
QDY55_RS24735 (4944474) 4944474..4946612 + 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
QDY55_RS24740 (4946797) 4946797..4947261 + 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QDY55_RS24745 (4947262) 4947262..4947552 - 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QDY55_RS24750 (4947542) 4947542..4947784 - 243 WP_064225789.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QDY55_RS24755 (4947976) 4947976..4948362 - 387 WP_001232246.1 cytochrome b562 -
QDY55_RS24760 (4948545) 4948545..4949897 - 1353 WP_001162171.1 metalloprotease PmbA -
QDY55_RS24765 (4949991) 4949991..4950542 + 552 WP_000166270.1 ribosome biogenesis factor YjgA -
QDY55_RS24770 (4950625) 4950625..4951998 - 1374 WP_001219792.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T277880 WP_001105433.1 NZ_CP122768:c4947552-4947262 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

>T277880 NZ_CP122768:c4947552-4947262 [Escherichia coli]
ATGAACTATGAGCTGGCGTTTGATCCGCGGGCGCTGAAAGAGTGGCAAAAACTGGGCGTGACAGTCCGGGAACAATTTAA
AAAAAAGCTTGAGGATGTGCTGAAAAGGCCGCGCAATCCATCGGCTAAACTGCGGGATTTACCGGACTGCTACAAAATTA
AGCTGCGCACACAGGGATATCGCCTGGTTTATCAGGTTAACGATAAAGAGTTGCTCGTGTTGGTGATAGCTATTGGTAAG
AGAGAGAACTCAGCCGTTTATGAAGACGCGACTAAACGGCTGGATGAGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9083.48 Da        Isoelectric Point: 5.1369

>AT277880 WP_064225789.1 NZ_CP122768:c4947784-4947542 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAGRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp

>AT277880 NZ_CP122768:c4947784-4947542 [Escherichia coli]
ATGGCCACACTTAACGTCCGCCTGGATGACAAACTGAAAAATGAGGCTTATGCGGTGCTGGAAAAATTAAATATCACGCC
TACTGAAGCAGGGCGACTGCTGTTTCAGTACGTTGCGGAAAATGGACGAATGCCGGTAAAAACGCTCACTGTCAGTGATA
GTGAAGAAGCCTTGTTACGCACTGTCAGGGAACGACTGGCCAACCCACAAGAGGCCATTAAGGTCCGACTGGATGAACTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A2S8JQB3

References