Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3692260..3692965 Replicon chromosome
Accession NZ_CP122768
Organism Escherichia coli strain ETEC1738

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag QDY55_RS18700 Protein ID WP_000539521.1
Coordinates 3692260..3692646 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag QDY55_RS18705 Protein ID WP_001280945.1
Coordinates 3692636..3692965 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY55_RS18680 (3688264) 3688264..3688890 + 627 WP_001314584.1 glutathione S-transferase GstB -
QDY55_RS18685 (3688887) 3688887..3690002 - 1116 WP_000555051.1 aldose sugar dehydrogenase YliI -
QDY55_RS18690 (3690113) 3690113..3690496 - 384 WP_000497137.1 biofilm formation regulator BssR -
QDY55_RS18695 (3690709) 3690709..3692034 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
QDY55_RS18700 (3692260) 3692260..3692646 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QDY55_RS18705 (3692636) 3692636..3692965 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
QDY55_RS18710 (3693035) 3693035..3694363 - 1329 WP_064225610.1 GGDEF domain-containing protein -
QDY55_RS18715 (3694371) 3694371..3696719 - 2349 WP_064225624.1 EAL domain-containing protein -
QDY55_RS18720 (3696897) 3696897..3697808 - 912 WP_001236044.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T277874 WP_000539521.1 NZ_CP122768:3692260-3692646 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT277874 WP_001280945.1 NZ_CP122768:3692636-3692965 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References