Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2569094..2569620 Replicon chromosome
Accession NZ_CP122768
Organism Escherichia coli strain ETEC1738

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag QDY55_RS12735 Protein ID WP_282870746.1
Coordinates 2569333..2569620 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag QDY55_RS12730 Protein ID WP_000534858.1
Coordinates 2569094..2569333 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY55_RS12705 (2564616) 2564616..2566103 + 1488 WP_000354584.1 hypothetical protein -
QDY55_RS12710 (2566473) 2566473..2567522 + 1050 Protein_2490 IS1202-like element ISEsa1 family transposase -
QDY55_RS12715 (2567643) 2567643..2567792 + 150 WP_011443592.1 protein YdfW -
QDY55_RS12720 (2568229) 2568229..2568561 - 333 WP_001301033.1 FlxA-like family protein -
QDY55_RS12725 (2568764) 2568764..2569069 - 306 WP_071593935.1 protein YdfV -
QDY55_RS12730 (2569094) 2569094..2569333 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
QDY55_RS12735 (2569333) 2569333..2569620 + 288 WP_282870746.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
QDY55_RS12740 (2569692) 2569692..2569847 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
QDY55_RS12745 (2570064) 2570064..2570315 + 252 WP_000981000.1 protein Rem -
QDY55_RS12750 (2570382) 2570382..2570660 + 279 WP_032140164.1 hypothetical protein -
QDY55_RS12755 (2570662) 2570662..2571711 + 1050 WP_001597879.1 DUF968 domain-containing protein -
QDY55_RS12760 (2571725) 2571725..2572477 + 753 WP_001047135.1 antitermination protein -
QDY55_RS12765 (2572755) 2572755..2572844 - 90 WP_120795389.1 hypothetical protein -
QDY55_RS12770 (2572899) 2572899..2573111 - 213 WP_000087756.1 cold shock-like protein CspF -
QDY55_RS12775 (2573412) 2573412..2573627 + 216 WP_000066484.1 cold shock-like protein CspB -
QDY55_RS12780 (2573991) 2573991..2574161 - 171 WP_001405948.1 putative zinc-binding protein YnfU -
QDY55_RS12785 (2574381) 2574381..2574596 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2552883..2605340 52457


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T277872 WP_282870746.1 NZ_CP122768:2569333-2569620 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVIESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT277872 WP_000534858.1 NZ_CP122768:2569094-2569333 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References