Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 989140..989794 Replicon chromosome
Accession NZ_CP122768
Organism Escherichia coli strain ETEC1738

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag QDY55_RS04800 Protein ID WP_000244781.1
Coordinates 989387..989794 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QDY55_RS04795 Protein ID WP_000354046.1
Coordinates 989140..989406 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY55_RS04775 (985228) 985228..986661 - 1434 WP_048969496.1 6-phospho-beta-glucosidase BglA -
QDY55_RS04780 (986706) 986706..987017 + 312 WP_001182951.1 N(4)-acetylcytidine aminohydrolase -
QDY55_RS04785 (987181) 987181..987840 + 660 WP_000250274.1 hemolysin III family protein -
QDY55_RS04790 (987917) 987917..988897 - 981 WP_001587401.1 tRNA-modifying protein YgfZ -
QDY55_RS04795 (989140) 989140..989406 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QDY55_RS04800 (989387) 989387..989794 + 408 WP_000244781.1 protein YgfX Toxin
QDY55_RS04805 (989834) 989834..990355 - 522 WP_001055874.1 flavodoxin FldB -
QDY55_RS04810 (990467) 990467..991363 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QDY55_RS04815 (991388) 991388..992098 + 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QDY55_RS04820 (992104) 992104..993837 + 1734 WP_000813175.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T277864 WP_000244781.1 NZ_CP122768:989387-989794 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT277864 WP_000354046.1 NZ_CP122768:989140-989406 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References