Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 358085..358716 Replicon chromosome
Accession NZ_CP122768
Organism Escherichia coli strain ETEC1738

Toxin (Protein)


Gene name hicA Uniprot ID L4J012
Locus tag QDY55_RS01640 Protein ID WP_001260301.1
Coordinates 358085..358360 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag QDY55_RS01645 Protein ID WP_000593555.1
Coordinates 358357..358716 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY55_RS01625 (353089) 353089..354156 + 1068 WP_000361510.1 HlyD family efflux transporter periplasmic adaptor subunit -
QDY55_RS01630 (354153) 354153..356888 + 2736 WP_000149144.1 ribosome-associated ATPase/putative transporter RbbA -
QDY55_RS01635 (356888) 356888..358012 + 1125 WP_001314210.1 ABC transporter permease -
QDY55_RS01640 (358085) 358085..358360 + 276 WP_001260301.1 type II toxin-antitoxin system HicA family toxin Toxin
QDY55_RS01645 (358357) 358357..358716 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QDY55_RS01650 (358836) 358836..359237 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
QDY55_RS01655 (359243) 359243..360049 - 807 WP_033870458.1 nickel import ATP-binding protein NikE -
QDY55_RS01660 (360046) 360046..360810 - 765 WP_001136211.1 nickel import ATP-binding protein NikD -
QDY55_RS01665 (360810) 360810..361643 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
QDY55_RS01670 (361640) 361640..362584 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10185.87 Da        Isoelectric Point: 10.6128

>T277860 WP_001260301.1 NZ_CP122768:358085-358360 [Escherichia coli]
MRTQVQALRKKQKNTLDQIFKSPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT277860 WP_000593555.1 NZ_CP122768:358357-358716 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB L4J012

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References