Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 218788..219400 Replicon chromosome
Accession NZ_CP122768
Organism Escherichia coli strain ETEC1738

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag QDY55_RS01040 Protein ID WP_000833473.1
Coordinates 218788..218973 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID L4IWR9
Locus tag QDY55_RS01045 Protein ID WP_000499744.1
Coordinates 218990..219400 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY55_RS01025 (214305) 214305..215456 + 1152 WP_000741501.1 L-threonine dehydrogenase -
QDY55_RS01030 (215657) 215657..217195 + 1539 WP_000183978.1 aldehyde dehydrogenase AldB -
QDY55_RS01035 (217236) 217236..218315 - 1080 Protein_205 type I restriction enzyme HsdR N-terminal domain-containing protein -
QDY55_RS01040 (218788) 218788..218973 + 186 WP_000833473.1 type II toxin-antitoxin system HicA family toxin Toxin
QDY55_RS01045 (218990) 218990..219400 + 411 WP_000499744.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QDY55_RS01050 (219472) 219472..221436 - 1965 WP_064226479.1 glycoside hydrolase family 127 protein -
QDY55_RS01055 (221447) 221447..222847 - 1401 WP_149448759.1 MFS transporter -
QDY55_RS01060 (223073) 223073..223888 + 816 WP_000891823.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T277859 WP_000833473.1 NZ_CP122768:218788-218973 [Escherichia coli]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15241.15 Da        Isoelectric Point: 4.5486

>AT277859 WP_000499744.1 NZ_CP122768:218990-219400 [Escherichia coli]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YXE2

Antitoxin

Source ID Structure
AlphaFold DB L4IWR9

References