Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 43695..44254 Replicon plasmid unnamed8
Accession NZ_CP122766
Organism Escherichia coli strain ETEC1739

Toxin (Protein)


Gene name relE Uniprot ID U9YB49
Locus tag QDW95_RS25710 Protein ID WP_000421259.1
Coordinates 43695..43970 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U9Y625
Locus tag QDW95_RS25715 Protein ID WP_001178087.1
Coordinates 43970..44254 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW95_RS25680 (38915) 38915..39967 + 1053 WP_000655519.1 hypothetical protein -
QDW95_RS25685 (40143) 40143..40745 + 603 WP_000521606.1 ProQ/FINO family protein -
QDW95_RS25690 (40801) 40801..41295 + 495 WP_015058884.1 hypothetical protein -
QDW95_RS25695 (41474) 41474..42310 - 837 WP_000480968.1 aminoglycoside O-phosphotransferase APH(6)-Id -
QDW95_RS25700 (42310) 42310..43113 - 804 WP_001082319.1 aminoglycoside O-phosphotransferase APH(3'')-Ib -
QDW95_RS25705 (43338) 43338..43589 - 252 WP_065553744.1 hypothetical protein -
QDW95_RS25710 (43695) 43695..43970 - 276 WP_000421259.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QDW95_RS25715 (43970) 43970..44254 - 285 WP_001178087.1 ribbon-helix-helix domain-containing protein Antitoxin
QDW95_RS25720 (45158) 45158..46189 - 1032 WP_000907852.1 plasmid replication initiator RepA -
QDW95_RS25725 (47195) 47195..47425 + 231 WP_228772074.1 ash family protein -
QDW95_RS25730 (47343) 47343..47630 + 288 WP_000074849.1 conjugal transfer protein TraA -
QDW95_RS25735 (48072) 48072..48605 + 534 WP_001372168.1 transcription termination/antitermination NusG family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aph(6)-Id / aph(3'')-Ib - 1..88929 88929


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10736.45 Da        Isoelectric Point: 9.9324

>T277857 WP_000421259.1 NZ_CP122766:c43970-43695 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELTGQTIY
VLRLWHTRENR

Download         Length: 276 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10488.92 Da        Isoelectric Point: 5.6558

>AT277857 WP_001178087.1 NZ_CP122766:c44254-43970 [Escherichia coli]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWIIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YB49

Antitoxin

Source ID Structure
AlphaFold DB U9Y625

References