Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 66779..67326 Replicon plasmid unnamed3
Accession NZ_CP122761
Organism Escherichia coli strain ETEC1739

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag QDW95_RS23910 Protein ID WP_001384452.1
Coordinates 67048..67326 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag QDW95_RS23905 Protein ID WP_000079941.1
Coordinates 66779..67048 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW95_RS23875 (61953) 61953..62411 - 459 Protein_75 transposase -
QDW95_RS23880 (62489) 62489..62638 - 150 Protein_76 transposase -
QDW95_RS23885 (63146) 63146..63364 + 219 WP_001353651.1 heat-stable enterotoxin ST-I group a -
QDW95_RS23895 (64948) 64948..65340 - 393 Protein_79 IS21-like element IS21 family helper ATPase IstB -
QDW95_RS23900 (65340) 65340..66512 - 1173 WP_015056461.1 IS21-like element IS21 family transposase -
QDW95_RS23905 (66779) 66779..67048 + 270 WP_000079941.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
QDW95_RS23910 (67048) 67048..67326 + 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
QDW95_RS23915 (67635) 67635..68777 + 1143 WP_158649904.1 YiiX/YebB-like N1pC/P60 family cysteine hydrolase -
QDW95_RS23920 (68750) 68750..68854 + 105 Protein_84 hypothetical protein -
QDW95_RS23925 (68866) 68866..69171 + 306 WP_000482654.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - hlyD / hlyD / hlyB / hlyA / hlyC 1..106236 106236
- inside IScluster/Tn - - 56115..81434 25319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T277849 WP_001384452.1 NZ_CP122761:67048-67326 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT277849 WP_000079941.1 NZ_CP122761:66779-67048 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References