Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4092056..4092632 Replicon chromosome
Accession NZ_CP122758
Organism Escherichia coli strain ETEC1739

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag QDW95_RS20165 Protein ID WP_001297643.1
Coordinates 4092345..4092632 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A829G8Z0
Locus tag QDW95_RS20160 Protein ID WP_000063156.1
Coordinates 4092056..4092358 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW95_RS20145 (4088652) 4088652..4090802 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
QDW95_RS20150 (4090852) 4090852..4091055 + 204 WP_000467859.1 YbdD/YjiX family protein -
QDW95_RS20155 (4091066) 4091066..4092022 + 957 WP_001297640.1 GTPase -
QDW95_RS20160 (4092056) 4092056..4092358 - 303 WP_000063156.1 BrnA antitoxin family protein Antitoxin
QDW95_RS20165 (4092345) 4092345..4092632 - 288 WP_001297643.1 BrnT family toxin Toxin
QDW95_RS20170 (4092831) 4092831..4093528 - 698 Protein_3947 IS1 family transposase -
QDW95_RS20175 (4093585) 4093585..4093680 + 96 Protein_3948 dienelactone hydrolase family protein -
QDW95_RS20180 (4093826) 4093826..4095058 + 1233 WP_024186283.1 multidrug efflux MFS transporter MdtM -
QDW95_RS20185 (4095099) 4095099..4096379 + 1281 WP_001037400.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T277846 WP_001297643.1 NZ_CP122758:c4092632-4092345 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11521.99 Da        Isoelectric Point: 9.4646

>AT277846 WP_000063156.1 NZ_CP122758:c4092358-4092056 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure
AlphaFold DB A0A829G8Z0

References