Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2518856..2519494 Replicon chromosome
Accession NZ_CP122758
Organism Escherichia coli strain ETEC1739

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag QDW95_RS12400 Protein ID WP_000813794.1
Coordinates 2519318..2519494 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QDW95_RS12395 Protein ID WP_001270286.1
Coordinates 2518856..2519272 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW95_RS12375 (2514008) 2514008..2514949 - 942 WP_087905458.1 ABC transporter permease -
QDW95_RS12380 (2514950) 2514950..2515963 - 1014 WP_097740840.1 ABC transporter ATP-binding protein -
QDW95_RS12385 (2515981) 2515981..2517126 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
QDW95_RS12390 (2517371) 2517371..2518777 - 1407 WP_000760585.1 PLP-dependent aminotransferase family protein -
QDW95_RS12395 (2518856) 2518856..2519272 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QDW95_RS12400 (2519318) 2519318..2519494 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QDW95_RS12405 (2519716) 2519716..2519946 + 231 WP_196010979.1 YncJ family protein -
QDW95_RS12410 (2520038) 2520038..2521999 - 1962 WP_282868944.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QDW95_RS12415 (2522072) 2522072..2522608 - 537 WP_000429133.1 DNA-binding transcriptional regulator SutR -
QDW95_RS12420 (2522700) 2522700..2523875 + 1176 WP_001236251.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2523915..2525180 1265


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T277843 WP_000813794.1 NZ_CP122758:c2519494-2519318 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT277843 WP_001270286.1 NZ_CP122758:c2519272-2518856 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References