Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 851920..852574 Replicon chromosome
Accession NZ_CP122758
Organism Escherichia coli strain ETEC1739

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag QDW95_RS04225 Protein ID WP_000244777.1
Coordinates 852167..852574 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QDW95_RS04220 Protein ID WP_000354046.1
Coordinates 851920..852186 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW95_RS04195 (847089) 847089..847832 + 744 WP_094313880.1 SDR family oxidoreductase -
QDW95_RS04200 (847889) 847889..849322 - 1434 WP_001336277.1 6-phospho-beta-glucosidase BglA -
QDW95_RS04205 (849367) 849367..849678 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
QDW95_RS04210 (849842) 849842..850501 + 660 WP_000250274.1 hemolysin III family protein -
QDW95_RS04215 (850697) 850697..851677 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
QDW95_RS04220 (851920) 851920..852186 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QDW95_RS04225 (852167) 852167..852574 + 408 WP_000244777.1 protein YgfX Toxin
QDW95_RS04230 (852614) 852614..853135 - 522 WP_001055874.1 flavodoxin FldB -
QDW95_RS04235 (853247) 853247..854143 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QDW95_RS04240 (854168) 854168..854878 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QDW95_RS04245 (854884) 854884..856617 + 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T277835 WP_000244777.1 NZ_CP122758:852167-852574 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT277835 WP_000354046.1 NZ_CP122758:851920-852186 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References