Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 64153..64712 Replicon plasmid unnamed5
Accession NZ_CP122732
Organism Escherichia coli strain ETEC1746

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag QDW99_RS24580 Protein ID WP_032084131.1
Coordinates 64437..64712 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag QDW99_RS24575 Protein ID WP_032084130.1
Coordinates 64153..64437 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW99_RS24550 (60279) 60279..60971 + 693 WP_001775033.1 fimbrial chaperone -
QDW99_RS24555 (61087) 61087..61467 + 381 WP_133301501.1 hypothetical protein -
QDW99_RS24560 (61618) 61618..62463 + 846 WP_032083800.1 hypothetical protein -
QDW99_RS24570 (63988) 63988..64068 - 81 Protein_79 ATP-binding protein -
QDW99_RS24575 (64153) 64153..64437 + 285 WP_032084130.1 ribbon-helix-helix domain-containing protein Antitoxin
QDW99_RS24580 (64437) 64437..64712 + 276 WP_032084131.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QDW99_RS24585 (64818) 64818..65021 + 204 Protein_82 hypothetical protein -
QDW99_RS24590 (65369) 65369..65715 + 347 Protein_83 DUF6404 family protein -
QDW99_RS24595 (65733) 65733..66167 - 435 Protein_84 hypothetical protein -
QDW99_RS24600 (66451) 66451..67374 - 924 WP_032084040.1 hypothetical protein -
QDW99_RS24605 (68267) 68267..69040 - 774 WP_032084041.1 YaiO family outer membrane beta-barrel protein -
QDW99_RS24610 (69042) 69042..69623 - 582 WP_050511315.1 acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - estIa 1..91044 91044


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10765.45 Da        Isoelectric Point: 9.9324

>T277830 WP_032084131.1 NZ_CP122732:64437-64712 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFSGEYEIRYELNGQTIY
VLRLWHTRENR

Download         Length: 276 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10517.92 Da        Isoelectric Point: 5.6558

>AT277830 WP_032084130.1 NZ_CP122732:64153-64437 [Escherichia coli]
MQMKNNSAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQTW
ADSLNTDNPLPVPR

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References