Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 50603..51150 Replicon plasmid unnamed1
Accession NZ_CP122728
Organism Escherichia coli strain ETEC1746

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag QDW99_RS23890 Protein ID WP_244461648.1
Coordinates 50872..51150 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A2H4TKA5
Locus tag QDW99_RS23885 Protein ID WP_000079937.1
Coordinates 50603..50872 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW99_RS23855 (45652) 45652..46479 - 828 WP_050511319.1 hypothetical protein -
QDW99_RS23860 (46806) 46806..47993 - 1188 WP_042634447.1 IS91 family transposase -
QDW99_RS23865 (47993) 47993..48358 - 366 WP_000124135.1 hypothetical protein -
QDW99_RS23870 (48635) 48635..49822 - 1188 WP_000937614.1 IS91-like element IS91 family transposase -
QDW99_RS23875 (49822) 49822..50187 - 366 WP_000124098.1 hypothetical protein -
QDW99_RS23880 (50206) 50206..50427 + 222 WP_000175571.1 hypothetical protein -
QDW99_RS23885 (50603) 50603..50872 + 270 WP_000079937.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
QDW99_RS23890 (50872) 50872..51150 + 279 WP_244461648.1 type II toxin-antitoxin system toxin YacB Toxin
QDW99_RS23895 (51414) 51414..52601 + 1188 WP_000905831.1 YiiX/YebB-like N1pC/P60 family cysteine hydrolase -
QDW99_RS23900 (52690) 52690..52995 + 306 WP_000482654.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..84442 84442
- inside IScluster/Tn - - 46806..61782 14976


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10732.29 Da        Isoelectric Point: 8.4615

>T277826 WP_244461648.1 NZ_CP122728:50872-51150 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLTAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10174.56 Da        Isoelectric Point: 10.1760

>AT277826 WP_000079937.1 NZ_CP122728:50603-50872 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLKHGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2H4TKA5

References