Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3566945..3567563 Replicon chromosome
Accession NZ_CP122727
Organism Escherichia coli strain ETEC1746

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QDW99_RS17665 Protein ID WP_001291435.1
Coordinates 3567345..3567563 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QDW99_RS17660 Protein ID WP_000344800.1
Coordinates 3566945..3567319 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW99_RS17650 (3562034) 3562034..3563227 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QDW99_RS17655 (3563250) 3563250..3566399 + 3150 WP_282868660.1 efflux RND transporter permease AcrB -
QDW99_RS17660 (3566945) 3566945..3567319 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QDW99_RS17665 (3567345) 3567345..3567563 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QDW99_RS17670 (3567735) 3567735..3568286 + 552 WP_000102564.1 maltose O-acetyltransferase -
QDW99_RS17675 (3568402) 3568402..3568872 + 471 WP_000136192.1 YlaC family protein -
QDW99_RS17680 (3569036) 3569036..3570586 + 1551 WP_032083478.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QDW99_RS17685 (3570628) 3570628..3570981 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QDW99_RS17695 (3571360) 3571360..3571671 + 312 WP_032083470.1 MGMT family protein -
QDW99_RS17700 (3571702) 3571702..3572274 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T277823 WP_001291435.1 NZ_CP122727:3567345-3567563 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT277823 WP_000344800.1 NZ_CP122727:3566945-3567319 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References