Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4494828..4495404 Replicon chromosome
Accession NZ_CP122722
Organism Escherichia coli strain ETEC1747

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag QDW91_RS22435 Protein ID WP_001297643.1
Coordinates 4495117..4495404 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A829G8Z0
Locus tag QDW91_RS22430 Protein ID WP_000063156.1
Coordinates 4494828..4495130 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW91_RS22415 (4491424) 4491424..4493574 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
QDW91_RS22420 (4493624) 4493624..4493827 + 204 WP_000467859.1 YbdD/YjiX family protein -
QDW91_RS22425 (4493838) 4493838..4494794 + 957 WP_001297640.1 GTPase -
QDW91_RS22430 (4494828) 4494828..4495130 - 303 WP_000063156.1 BrnA antitoxin family protein Antitoxin
QDW91_RS22435 (4495117) 4495117..4495404 - 288 WP_001297643.1 BrnT family toxin Toxin
QDW91_RS22440 (4495603) 4495603..4496300 - 698 Protein_4395 IS1 family transposase -
QDW91_RS22445 (4496357) 4496357..4496452 + 96 Protein_4396 dienelactone hydrolase family protein -
QDW91_RS22450 (4496598) 4496598..4497830 + 1233 WP_001380906.1 multidrug efflux MFS transporter MdtM -
QDW91_RS22455 (4497871) 4497871..4499151 + 1281 WP_001037380.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T277798 WP_001297643.1 NZ_CP122722:c4495404-4495117 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11521.99 Da        Isoelectric Point: 9.4646

>AT277798 WP_000063156.1 NZ_CP122722:c4495130-4494828 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure
AlphaFold DB A0A829G8Z0

References