Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3914725..3915343 Replicon chromosome
Accession NZ_CP122722
Organism Escherichia coli strain ETEC1747

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QDW91_RS19720 Protein ID WP_001291435.1
Coordinates 3915125..3915343 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QDW91_RS19715 Protein ID WP_000344800.1
Coordinates 3914725..3915099 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW91_RS19705 (3909814) 3909814..3911007 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QDW91_RS19710 (3911030) 3911030..3914179 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QDW91_RS19715 (3914725) 3914725..3915099 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QDW91_RS19720 (3915125) 3915125..3915343 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QDW91_RS19725 (3915515) 3915515..3916066 + 552 WP_000102568.1 maltose O-acetyltransferase -
QDW91_RS19730 (3916182) 3916182..3916652 + 471 WP_000136192.1 YlaC family protein -
QDW91_RS19735 (3916816) 3916816..3918366 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QDW91_RS19740 (3918408) 3918408..3918761 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QDW91_RS19750 (3919140) 3919140..3919451 + 312 WP_000409911.1 MGMT family protein -
QDW91_RS19755 (3919482) 3919482..3920054 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T277797 WP_001291435.1 NZ_CP122722:3915125-3915343 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT277797 WP_000344800.1 NZ_CP122722:3914725-3915099 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References