Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2010969..2011801 Replicon chromosome
Accession NZ_CP122722
Organism Escherichia coli strain ETEC1747

Toxin (Protein)


Gene name yeeV Uniprot ID A7ZVJ9
Locus tag QDW91_RS10010 Protein ID WP_000854765.1
Coordinates 2010969..2011343 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8S7UAZ9
Locus tag QDW91_RS10015 Protein ID WP_001372808.1
Coordinates 2011433..2011801 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW91_RS09975 (2006428) 2006428..2006757 + 330 WP_000450409.1 DUF496 family protein -
QDW91_RS09980 (2006858) 2006858..2007124 - 267 WP_001360325.1 EutP/PduV family microcompartment system protein -
QDW91_RS09985 (2007314) 2007314..2008096 - 783 WP_001317493.1 IS21-like element IS100kyp family helper ATPase IstB -
QDW91_RS09990 (2008093) 2008093..2009115 - 1023 WP_001372384.1 IS21-like element IS100 family transposase -
QDW91_RS09995 (2009453) 2009453..2009842 - 390 WP_077249349.1 transposase -
QDW91_RS10000 (2010640) 2010640..2010720 - 81 Protein_1961 hypothetical protein -
QDW91_RS10005 (2010820) 2010820..2010972 - 153 Protein_1962 DUF5983 family protein -
QDW91_RS10010 (2010969) 2010969..2011343 - 375 WP_000854765.1 TA system toxin CbtA family protein Toxin
QDW91_RS10015 (2011433) 2011433..2011801 - 369 WP_001372808.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QDW91_RS10020 (2011964) 2011964..2012186 - 223 Protein_1965 DUF987 domain-containing protein -
QDW91_RS10025 (2012255) 2012255..2012731 - 477 WP_001186770.1 RadC family protein -
QDW91_RS10030 (2012747) 2012747..2013220 - 474 WP_001372806.1 antirestriction protein -
QDW91_RS10035 (2013562) 2013562..2014380 - 819 WP_001234651.1 DUF932 domain-containing protein -
QDW91_RS10040 (2014498) 2014498..2014693 - 196 Protein_1969 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13970.98 Da        Isoelectric Point: 7.2909

>T277786 WP_000854765.1 NZ_CP122722:c2011343-2010969 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK

Download         Length: 375 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13551.25 Da        Isoelectric Point: 5.4492

>AT277786 WP_001372808.1 NZ_CP122722:c2011801-2011433 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGTRLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A7ZVJ9

Antitoxin

Source ID Structure

References