Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1461438..1462063 Replicon chromosome
Accession NZ_CP122722
Organism Escherichia coli strain ETEC1747

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QDW91_RS07340 Protein ID WP_000911330.1
Coordinates 1461665..1462063 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag QDW91_RS07335 Protein ID WP_000450524.1
Coordinates 1461438..1461665 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW91_RS07310 (1457242) 1457242..1457712 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
QDW91_RS07315 (1457712) 1457712..1458284 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
QDW91_RS07320 (1458430) 1458430..1459308 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
QDW91_RS07325 (1459325) 1459325..1460359 + 1035 WP_001384714.1 outer membrane protein assembly factor BamC -
QDW91_RS07330 (1460572) 1460572..1461285 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
QDW91_RS07335 (1461438) 1461438..1461665 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
QDW91_RS07340 (1461665) 1461665..1462063 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
QDW91_RS07345 (1462210) 1462210..1463073 + 864 WP_001267507.1 neutral zinc metallopeptidase -
QDW91_RS07350 (1463088) 1463088..1465103 + 2016 WP_000829335.1 tRNA cytosine(34) acetyltransferase TmcA -
QDW91_RS07355 (1465177) 1465177..1465875 + 699 WP_000679812.1 esterase -
QDW91_RS07360 (1465985) 1465985..1466185 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T277784 WP_000911330.1 NZ_CP122722:1461665-1462063 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT277784 WP_000450524.1 NZ_CP122722:1461438-1461665 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References