Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 33297..33844 Replicon plasmid unnamed1
Accession NZ_CP122720
Organism Escherichia coli strain ETEC1748

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag QDW92_RS25245 Protein ID WP_244461648.1
Coordinates 33566..33844 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A2H4TKA5
Locus tag QDW92_RS25240 Protein ID WP_000079937.1
Coordinates 33297..33566 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW92_RS25225 (29341) 29341..29901 - 561 WP_001161490.1 recombinase family protein -
QDW92_RS25230 (30211) 30211..31788 + 1578 WP_001323889.1 PAS domain-containing methyl-accepting chemotaxis protein -
QDW92_RS25235 (32084) 32084..33121 + 1038 WP_032083970.1 DNA-binding protein -
QDW92_RS25240 (33297) 33297..33566 + 270 WP_000079937.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
QDW92_RS25245 (33566) 33566..33844 + 279 WP_244461648.1 type II toxin-antitoxin system toxin YacB Toxin
QDW92_RS25250 (34108) 34108..34719 + 612 WP_282843241.1 YiiX/YebB-like N1pC/P60 family cysteine hydrolase -
QDW92_RS25255 (34737) 34737..35294 + 558 WP_282843242.1 hypothetical protein -
QDW92_RS25260 (35267) 35267..35371 + 105 Protein_46 hypothetical protein -
QDW92_RS25265 (35383) 35383..35688 + 306 WP_000482654.1 hypothetical protein -
QDW92_RS25275 (37061) 37061..37758 + 698 WP_236281370.1 IS1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..47961 47961


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10732.29 Da        Isoelectric Point: 8.4615

>T277775 WP_244461648.1 NZ_CP122720:33566-33844 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLTAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10174.56 Da        Isoelectric Point: 10.1760

>AT277775 WP_000079937.1 NZ_CP122720:33297-33566 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLKHGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2H4TKA5

References