Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4579518..4580027 Replicon chromosome
Accession NZ_CP122719
Organism Escherichia coli strain ETEC1748

Toxin (Protein)


Gene name ghoT Uniprot ID -
Locus tag QDW92_RS22585 Protein ID WP_089514152.1
Coordinates 4579518..4579703 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QDW92_RS22590 Protein ID WP_000398619.1
Coordinates 4579731..4580027 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW92_RS22575 (4576201) 4576201..4577658 + 1458 WP_001550473.1 dipeptide/tripeptide permease DtpC -
QDW92_RS22580 (4577895) 4577895..4579412 + 1518 WP_001295074.1 lysine--tRNA ligase -
QDW92_RS22585 (4579518) 4579518..4579703 - 186 WP_089514152.1 type V toxin-antitoxin system toxin GhoT Toxin
QDW92_RS22590 (4579731) 4579731..4580027 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QDW92_RS22595 (4580254) 4580254..4580526 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
QDW92_RS22600 (4580538) 4580538..4580768 - 231 WP_001550470.1 4Fe-4S mono-cluster protein YjdI -
QDW92_RS22605 (4580948) 4580948..4582579 + 1632 WP_001216482.1 sensor histidine kinase -
QDW92_RS22610 (4582576) 4582576..4583295 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4540834..4580027 39193


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-54)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6988.54 Da        Isoelectric Point: 10.2380

>T277773 WP_089514152.1 NZ_CP122719:c4579703-4579518 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFLSFRSCS

Download         Length: 186 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT277773 WP_000398619.1 NZ_CP122719:c4580027-4579731 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References