Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4351591..4352167 Replicon chromosome
Accession NZ_CP122719
Organism Escherichia coli strain ETEC1748

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag QDW92_RS21395 Protein ID WP_001297643.1
Coordinates 4351880..4352167 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A080I7H7
Locus tag QDW92_RS21390 Protein ID WP_000063160.1
Coordinates 4351591..4351893 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW92_RS21375 (4348187) 4348187..4350337 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
QDW92_RS21380 (4350387) 4350387..4350590 + 204 WP_000467859.1 YbdD/YjiX family protein -
QDW92_RS21385 (4350601) 4350601..4351557 + 957 WP_001297640.1 GTPase -
QDW92_RS21390 (4351591) 4351591..4351893 - 303 WP_000063160.1 BrnA antitoxin family protein Antitoxin
QDW92_RS21395 (4351880) 4351880..4352167 - 288 WP_001297643.1 BrnT family toxin Toxin
QDW92_RS21400 (4352366) 4352366..4353063 - 698 Protein_4189 IS1 family transposase -
QDW92_RS21405 (4353120) 4353120..4353215 + 96 Protein_4190 dienelactone hydrolase family protein -
QDW92_RS21410 (4353361) 4353361..4354593 + 1233 WP_282843236.1 multidrug efflux MFS transporter MdtM -
QDW92_RS21415 (4354634) 4354634..4355914 + 1281 WP_001037400.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T277771 WP_001297643.1 NZ_CP122719:c4352167-4351880 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11552.01 Da        Isoelectric Point: 9.4646

>AT277771 WP_000063160.1 NZ_CP122719:c4351893-4351591 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALTNKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure
AlphaFold DB A0A080I7H7

References