Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3772114..3772732 Replicon chromosome
Accession NZ_CP122719
Organism Escherichia coli strain ETEC1748

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QDW92_RS18615 Protein ID WP_001291435.1
Coordinates 3772514..3772732 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QDW92_RS18610 Protein ID WP_000344800.1
Coordinates 3772114..3772488 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW92_RS18600 (3767203) 3767203..3768396 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QDW92_RS18605 (3768419) 3768419..3771568 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
QDW92_RS18610 (3772114) 3772114..3772488 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QDW92_RS18615 (3772514) 3772514..3772732 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QDW92_RS18620 (3772904) 3772904..3773455 + 552 WP_063118620.1 maltose O-acetyltransferase -
QDW92_RS18625 (3773571) 3773571..3774041 + 471 WP_063085325.1 YlaC family protein -
QDW92_RS18630 (3774205) 3774205..3775755 + 1551 WP_063085326.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QDW92_RS18635 (3775797) 3775797..3776150 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QDW92_RS18645 (3776529) 3776529..3776840 + 312 WP_000409911.1 MGMT family protein -
QDW92_RS18650 (3776871) 3776871..3777443 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T277768 WP_001291435.1 NZ_CP122719:3772514-3772732 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT277768 WP_000344800.1 NZ_CP122719:3772114-3772488 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References