Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3354159..3354864 Replicon chromosome
Accession NZ_CP122719
Organism Escherichia coli strain ETEC1748

Toxin (Protein)


Gene name relE Uniprot ID A0A3A6SJV3
Locus tag QDW92_RS16700 Protein ID WP_063085620.1
Coordinates 3354159..3354545 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag QDW92_RS16705 Protein ID WP_001280945.1
Coordinates 3354535..3354864 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW92_RS16680 (3350163) 3350163..3350789 + 627 WP_001314584.1 glutathione S-transferase GstB -
QDW92_RS16685 (3350786) 3350786..3351901 - 1116 WP_063085618.1 aldose sugar dehydrogenase YliI -
QDW92_RS16690 (3352012) 3352012..3352395 - 384 WP_000497137.1 biofilm formation regulator BssR -
QDW92_RS16695 (3352608) 3352608..3353933 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
QDW92_RS16700 (3354159) 3354159..3354545 + 387 WP_063085620.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QDW92_RS16705 (3354535) 3354535..3354864 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
QDW92_RS16710 (3354934) 3354934..3356262 - 1329 WP_000086873.1 GGDEF domain-containing protein -
QDW92_RS16715 (3356270) 3356270..3358618 - 2349 WP_021523051.1 EAL domain-containing protein -
QDW92_RS16720 (3358796) 3358796..3359707 - 912 WP_001236019.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14280.45 Da        Isoelectric Point: 9.9296

>T277767 WP_063085620.1 NZ_CP122719:3354159-3354545 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSTKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT277767 WP_001280945.1 NZ_CP122719:3354535-3354864 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A6SJV3

Antitoxin

Source ID Structure

References