Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2541153..2542741 Replicon chromosome
Accession NZ_CP122719
Organism Escherichia coli strain ETEC1748

Toxin (Protein)


Gene name hipA Uniprot ID A0A3A6RNL0
Locus tag QDW92_RS12580 Protein ID WP_063085289.1
Coordinates 2541419..2542741 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QDW92_RS12575 Protein ID WP_001296726.1
Coordinates 2541153..2541419 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW92_RS12575 (2541153) 2541153..2541419 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QDW92_RS12580 (2541419) 2541419..2542741 + 1323 WP_063085289.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
QDW92_RS12585 (2543139) 2543139..2544036 - 898 Protein_2463 LysR substrate-binding domain-containing protein -
QDW92_RS12590 (2544176) 2544176..2544484 + 309 WP_001221046.1 hypothetical protein -
QDW92_RS12595 (2544493) 2544493..2545182 + 690 WP_000801314.1 type 1 glutamine amidotransferase domain-containing protein -
QDW92_RS12600 (2545244) 2545244..2546191 + 948 WP_063085290.1 aldo/keto reductase -
QDW92_RS12605 (2546294) 2546294..2546449 + 156 WP_001327998.1 hypothetical protein -
QDW92_RS12610 (2546409) 2546409..2546828 + 420 WP_001314733.1 amidohydrolase family protein -
QDW92_RS12615 (2546818) 2546818..2546970 + 153 WP_001314732.1 amidohydrolase family protein -
QDW92_RS12620 (2547120) 2547120..2547692 + 573 WP_000789914.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49313.91 Da        Isoelectric Point: 8.5849

>T277761 WP_063085289.1 NZ_CP122719:2541419-2542741 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLANRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEQLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDHVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT277761 WP_001296726.1 NZ_CP122719:2541153-2541419 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A6RNL0

Antitoxin

Source ID Structure

References