Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 909644..910298 Replicon chromosome
Accession NZ_CP122719
Organism Escherichia coli strain ETEC1748

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag QDW92_RS04380 Protein ID WP_000244781.1
Coordinates 909891..910298 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QDW92_RS04375 Protein ID WP_000354046.1
Coordinates 909644..909910 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW92_RS04355 (905732) 905732..907165 - 1434 WP_063085817.1 6-phospho-beta-glucosidase BglA -
QDW92_RS04360 (907210) 907210..907521 + 312 WP_001182952.1 N(4)-acetylcytidine aminohydrolase -
QDW92_RS04365 (907685) 907685..908344 + 660 WP_000250269.1 hemolysin III family protein -
QDW92_RS04370 (908421) 908421..909401 - 981 WP_000886050.1 tRNA-modifying protein YgfZ -
QDW92_RS04375 (909644) 909644..909910 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QDW92_RS04380 (909891) 909891..910298 + 408 WP_000244781.1 protein YgfX Toxin
QDW92_RS04385 (910338) 910338..910859 - 522 WP_001055888.1 flavodoxin FldB -
QDW92_RS04390 (910971) 910971..911867 + 897 WP_000806652.1 site-specific tyrosine recombinase XerD -
QDW92_RS04395 (911892) 911892..912602 + 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QDW92_RS04400 (912608) 912608..914341 + 1734 WP_000813177.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T277753 WP_000244781.1 NZ_CP122719:909891-910298 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT277753 WP_000354046.1 NZ_CP122719:909644-909910 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References