Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4787853..4788350 Replicon chromosome
Accession NZ_CP122712
Organism Escherichia coli strain ETEC1749

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QDX02_RS24180 Protein ID WP_001173343.1
Coordinates 4787853..4788026 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QDX02_RS24185 Protein ID WP_000398619.1
Coordinates 4788054..4788350 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX02_RS24170 (4784518) 4784518..4785975 + 1458 WP_032167241.1 dipeptide/tripeptide permease DtpC -
QDX02_RS24175 (4786212) 4786212..4787729 + 1518 WP_001295074.1 lysine--tRNA ligase -
QDX02_RS24180 (4787853) 4787853..4788026 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QDX02_RS24185 (4788054) 4788054..4788350 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QDX02_RS24190 (4788577) 4788577..4788849 - 273 WP_000405651.1 GNAT family N-acetyltransferase -
QDX02_RS24195 (4788861) 4788861..4789091 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
QDX02_RS24200 (4789272) 4789272..4790903 + 1632 WP_001216477.1 sensor histidine kinase -
QDX02_RS24205 (4790900) 4790900..4791619 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T277742 WP_001173343.1 NZ_CP122712:c4788026-4787853 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT277742 WP_000398619.1 NZ_CP122712:c4788350-4788054 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References