Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4525044..4525620 Replicon chromosome
Accession NZ_CP122712
Organism Escherichia coli strain ETEC1749

Toxin (Protein)


Gene name shpA Uniprot ID A0A2X2XYK1
Locus tag QDX02_RS22810 Protein ID WP_001360091.1
Coordinates 4525333..4525620 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A829G8Z0
Locus tag QDX02_RS22805 Protein ID WP_000063156.1
Coordinates 4525044..4525346 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX02_RS22790 (4521640) 4521640..4523790 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
QDX02_RS22795 (4523840) 4523840..4524043 + 204 WP_000467859.1 YbdD/YjiX family protein -
QDX02_RS22800 (4524054) 4524054..4525010 + 957 WP_001297640.1 GTPase -
QDX02_RS22805 (4525044) 4525044..4525346 - 303 WP_000063156.1 BrnA antitoxin family protein Antitoxin
QDX02_RS22810 (4525333) 4525333..4525620 - 288 WP_001360091.1 BrnT family toxin Toxin
QDX02_RS22815 (4525819) 4525819..4526516 - 698 Protein_4469 IS1-like element IS1F family transposase -
QDX02_RS22820 (4526573) 4526573..4526668 + 96 Protein_4470 dienelactone hydrolase family protein -
QDX02_RS22825 (4526814) 4526814..4528046 + 1233 WP_015675357.1 multidrug efflux MFS transporter MdtM -
QDX02_RS22830 (4528087) 4528087..4529367 + 1281 WP_001037377.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11325.80 Da        Isoelectric Point: 6.8821

>T277741 WP_001360091.1 NZ_CP122712:c4525620-4525333 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKTDRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11521.99 Da        Isoelectric Point: 9.4646

>AT277741 WP_000063156.1 NZ_CP122712:c4525346-4525044 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X2XYK1

Antitoxin

Source ID Structure
AlphaFold DB A0A829G8Z0

References