Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3946071..3946689 Replicon chromosome
Accession NZ_CP122712
Organism Escherichia coli strain ETEC1749

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QDX02_RS20005 Protein ID WP_001291435.1
Coordinates 3946471..3946689 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QDX02_RS20000 Protein ID WP_000344800.1
Coordinates 3946071..3946445 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX02_RS19990 (3941160) 3941160..3942353 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QDX02_RS19995 (3942376) 3942376..3945525 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QDX02_RS20000 (3946071) 3946071..3946445 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QDX02_RS20005 (3946471) 3946471..3946689 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QDX02_RS20010 (3946861) 3946861..3947412 + 552 WP_000102564.1 maltose O-acetyltransferase -
QDX02_RS20015 (3947528) 3947528..3947998 + 471 WP_000136192.1 YlaC family protein -
QDX02_RS20020 (3948162) 3948162..3949712 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QDX02_RS20025 (3949754) 3949754..3950107 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QDX02_RS20035 (3950486) 3950486..3950797 + 312 WP_000409911.1 MGMT family protein -
QDX02_RS20040 (3950828) 3950828..3951400 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T277738 WP_001291435.1 NZ_CP122712:3946471-3946689 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT277738 WP_000344800.1 NZ_CP122712:3946071-3946445 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References