Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3178717..3179188 Replicon chromosome
Accession NZ_CP122712
Organism Escherichia coli strain ETEC1749

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag QDX02_RS16205 Protein ID WP_001303511.1
Coordinates 3178910..3179188 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag QDX02_RS16200 Protein ID WP_001302048.1
Coordinates 3178717..3178908 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX02_RS16145 (3173933) 3173933..3174088 - 156 WP_168997827.1 type I toxin-antitoxin system toxin HokD -
QDX02_RS16150 (3174342) 3174342..3174599 - 258 WP_001176099.1 hypothetical protein -
QDX02_RS16155 (3174739) 3174739..3175254 - 516 WP_001289996.1 hypothetical protein -
QDX02_RS16160 (3175251) 3175251..3175427 - 177 WP_000753061.1 hypothetical protein -
QDX02_RS16165 (3175420) 3175420..3175602 - 183 WP_001224945.1 hypothetical protein -
QDX02_RS16170 (3175698) 3175698..3175898 - 201 WP_001546006.1 hypothetical protein -
QDX02_RS16175 (3175895) 3175895..3176321 - 427 Protein_3172 DUF977 family protein -
QDX02_RS16180 (3176362) 3176362..3177432 - 1071 WP_032166946.1 phage replisome organizer -
QDX02_RS16185 (3177504) 3177504..3177929 - 426 WP_000693883.1 toxin YdaT family protein -
QDX02_RS16190 (3177926) 3177926..3178228 - 303 WP_000172735.1 transcriptional regulator -
QDX02_RS16195 (3178340) 3178340..3178696 + 357 WP_282842677.1 hypothetical protein -
QDX02_RS16200 (3178717) 3178717..3178908 + 192 WP_001302048.1 hypothetical protein Antitoxin
QDX02_RS16205 (3178910) 3178910..3179188 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QDX02_RS16210 (3179480) 3179480..3179635 + 156 WP_000379575.1 DUF1391 family protein -
QDX02_RS16215 (3179637) 3179637..3179765 + 129 WP_000344974.1 protein YdfB -
QDX02_RS16220 (3179795) 3179795..3180013 + 219 WP_001171942.1 protein YdfC -
QDX02_RS16225 (3180036) 3180036..3180443 + 408 WP_032166907.1 hypothetical protein -
QDX02_RS16230 (3180421) 3180421..3180654 - 234 WP_000920491.1 hypothetical protein -
QDX02_RS16235 (3181215) 3181215..3181403 + 189 WP_000449192.1 cell division inhibition protein DicB -
QDX02_RS16240 (3181400) 3181400..3181591 + 192 WP_032166926.1 DUF1482 family protein -
QDX02_RS16245 (3181684) 3181684..3184155 + 2472 WP_032084640.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3128465..3194410 65945


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T277737 WP_001303511.1 NZ_CP122712:3178910-3179188 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT277737 WP_001302048.1 NZ_CP122712:3178717-3178908 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References