Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2607681..2609269 Replicon chromosome
Accession NZ_CP122712
Organism Escherichia coli strain ETEC1749

Toxin (Protein)


Gene name hipA Uniprot ID S1ELM3
Locus tag QDX02_RS13080 Protein ID WP_001125439.1
Coordinates 2607681..2609003 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QDX02_RS13085 Protein ID WP_001301023.1
Coordinates 2609003..2609269 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX02_RS13040 (2602858) 2602858..2603145 - 288 WP_062886943.1 DUF2523 family protein -
QDX02_RS13045 (2603156) 2603156..2604442 - 1287 WP_144049692.1 hypothetical protein -
QDX02_RS13050 (2604526) 2604526..2604744 - 219 WP_115194609.1 major capsid protein -
QDX02_RS13055 (2604992) 2604992..2605282 - 291 WP_024160666.1 hypothetical protein -
QDX02_RS13060 (2605299) 2605299..2606414 - 1116 WP_097758693.1 phage/plasmid replication protein -
QDX02_RS13065 (2606592) 2606592..2606747 + 156 WP_250113132.1 hypothetical protein -
QDX02_RS13070 (2606890) 2606890..2607300 + 411 WP_282842669.1 hypothetical protein -
QDX02_RS13075 (2607297) 2607297..2607503 + 207 WP_097156357.1 hypothetical protein -
QDX02_RS13080 (2607681) 2607681..2609003 - 1323 WP_001125439.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
QDX02_RS13085 (2609003) 2609003..2609269 - 267 WP_001301023.1 type II toxin-antitoxin system antitoxin HipB Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49275.82 Da        Isoelectric Point: 8.2482

>T277731 WP_001125439.1 NZ_CP122712:c2609003-2607681 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.38 Da        Isoelectric Point: 6.2267

>AT277731 WP_001301023.1 NZ_CP122712:c2609269-2609003 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAKNASPES
TEQQNLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5K98
PDB 3TPV
PDB 3DNV
PDB 3TPD
PDB 3HZI
PDB 3FBR
PDB 4YG7
PDB 3TPE
PDB 2WIU
PDB 3DNT
PDB 3TPB
PDB 3TPT
PDB 3DNU

Antitoxin

Source ID Structure

References