Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2471586..2472224 Replicon chromosome
Accession NZ_CP122712
Organism Escherichia coli strain ETEC1749

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag QDX02_RS12415 Protein ID WP_000813794.1
Coordinates 2471586..2471762 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QDX02_RS12420 Protein ID WP_001270286.1
Coordinates 2471808..2472224 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX02_RS12395 (2467205) 2467205..2468380 - 1176 WP_001236265.1 BenE family transporter YdcO -
QDX02_RS12400 (2468472) 2468472..2469008 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
QDX02_RS12405 (2469081) 2469081..2471042 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QDX02_RS12410 (2471134) 2471134..2471364 - 231 WP_000494244.1 YncJ family protein -
QDX02_RS12415 (2471586) 2471586..2471762 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QDX02_RS12420 (2471808) 2471808..2472224 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QDX02_RS12425 (2472303) 2472303..2473712 + 1410 WP_000760625.1 PLP-dependent aminotransferase family protein -
QDX02_RS12430 (2473954) 2473954..2475099 + 1146 WP_000047429.1 ABC transporter substrate-binding protein -
QDX02_RS12435 (2475117) 2475117..2476130 + 1014 WP_000220393.1 ABC transporter ATP-binding protein -
QDX02_RS12440 (2476131) 2476131..2477072 + 942 WP_001251319.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T277730 WP_000813794.1 NZ_CP122712:2471586-2471762 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT277730 WP_001270286.1 NZ_CP122712:2471808-2472224 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References