Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1456073..1456868 Replicon chromosome
Accession NC_017906
Organism Escherichia coli Xuzhou21

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag CDCO157_RS07285 Protein ID WP_000854914.1
Coordinates 1456494..1456868 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag CDCO157_RS07280 Protein ID WP_001280954.1
Coordinates 1456073..1456447 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDCO157_RS07240 1451428..1452333 + 906 WP_000203541.1 chemotaxis protein -
CDCO157_RS07245 1452330..1453400 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
CDCO157_RS07255 1453740..1454558 + 819 WP_001234682.1 DUF945 domain-containing protein -
CDCO157_RS07260 1454649..1455134 + 486 WP_000214398.1 antirestriction protein -
CDCO157_RS07265 1455150..1455626 + 477 WP_001186738.1 RadC family protein -
CDCO157_RS07270 1455689..1455910 + 222 WP_001220314.1 DUF987 domain-containing protein -
CDCO157_RS07280 1456073..1456447 + 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CDCO157_RS07285 1456494..1456868 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
CDCO157_RS07290 1456865..1457356 + 492 WP_000976853.1 hypothetical protein -
CDCO157_RS07295 1457368..1457565 + 198 WP_000839282.1 DUF957 domain-containing protein -
CDCO157_RS07300 1457650..1458492 + 843 WP_001280481.1 DUF4942 domain-containing protein -
CDCO157_RS07310 1458963..1459901 + 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
CDCO157_RS07315 1459956..1460693 + 738 WP_000283664.1 zinc-binding phosphatase -
CDCO157_RS07320 1460717..1461271 + 555 WP_001001917.1 molecular chaperone YcdY -
CDCO157_RS07325 1461373..1461864 + 492 WP_001301587.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T27772 WP_000854914.1 NC_017906:1456494-1456868 [Escherichia coli Xuzhou21]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T27772 NC_017906:1456494-1456868 [Escherichia coli Xuzhou21]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT27772 WP_001280954.1 NC_017906:1456073-1456447 [Escherichia coli Xuzhou21]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT27772 NC_017906:1456073-1456447 [Escherichia coli Xuzhou21]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References