Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 48446..49005 Replicon plasmid unnamed2
Accession NZ_CP122687
Organism Escherichia coli strain ETEC4067

Toxin (Protein)


Gene name relE Uniprot ID A0A733EV64
Locus tag QDX30_RS25750 Protein ID WP_001582571.1
Coordinates 48730..49005 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C1J8K5
Locus tag QDX30_RS25745 Protein ID WP_001178089.1
Coordinates 48446..48730 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX30_RS25725 (44091) 44091..44624 - 534 WP_001306770.1 transcription termination/antitermination NusG family protein -
QDX30_RS25730 (45066) 45066..45353 - 288 WP_000074849.1 conjugal transfer protein TraA -
QDX30_RS25735 (45271) 45271..45501 - 231 WP_228772074.1 ash family protein -
QDX30_RS25740 (46507) 46507..47538 + 1032 WP_000907861.1 plasmid replication initiator RepA -
QDX30_RS25745 (48446) 48446..48730 + 285 WP_001178089.1 ribbon-helix-helix domain-containing protein Antitoxin
QDX30_RS25750 (48730) 48730..49005 + 276 WP_001582571.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QDX30_RS25755 (49111) 49111..49314 + 204 Protein_52 hypothetical protein -
QDX30_RS25760 (49584) 49584..49850 - 267 WP_000627829.1 hypothetical protein -
QDX30_RS25765 (49850) 49850..50344 - 495 WP_001582574.1 hypothetical protein -
QDX30_RS25770 (50400) 50400..51002 - 603 WP_000517695.1 ProQ/FINO family protein -
QDX30_RS25775 (51356) 51356..52771 + 1416 WP_029397060.1 protein YagA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaTEM-1B - 1..93031 93031


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10807.48 Da        Isoelectric Point: 9.5296

>T277715 WP_001582571.1 NZ_CP122687:48730-49005 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNDQTIY
VLRLWHTRENR

Download         Length: 276 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10474.89 Da        Isoelectric Point: 5.6558

>AT277715 WP_001178089.1 NZ_CP122687:48446-48730 [Escherichia coli]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A733EV64

Antitoxin

Source ID Structure
AlphaFold DB A0A731IHA8

References