Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4591381..4591878 Replicon chromosome
Accession NZ_CP122685
Organism Escherichia coli strain ETEC4067

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QDX30_RS22680 Protein ID WP_001173343.1
Coordinates 4591381..4591554 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QDX30_RS22685 Protein ID WP_000398619.1
Coordinates 4591582..4591878 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX30_RS22670 (4588051) 4588051..4589508 + 1458 WP_001550473.1 dipeptide/tripeptide permease DtpC -
QDX30_RS22675 (4589745) 4589745..4591262 + 1518 WP_001295074.1 lysine--tRNA ligase -
QDX30_RS22680 (4591381) 4591381..4591554 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QDX30_RS22685 (4591582) 4591582..4591878 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QDX30_RS22690 (4592105) 4592105..4592377 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
QDX30_RS22695 (4592389) 4592389..4592619 - 231 WP_001550470.1 4Fe-4S mono-cluster protein YjdI -
QDX30_RS22700 (4592799) 4592799..4594430 + 1632 WP_001216482.1 sensor histidine kinase -
QDX30_RS22705 (4594427) 4594427..4595146 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4552449..4591878 39429


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T277710 WP_001173343.1 NZ_CP122685:c4591554-4591381 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT277710 WP_000398619.1 NZ_CP122685:c4591878-4591582 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References