Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3771226..3771844 Replicon chromosome
Accession NZ_CP122685
Organism Escherichia coli strain ETEC4067

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QDX30_RS18625 Protein ID WP_001291435.1
Coordinates 3771626..3771844 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QDX30_RS18620 Protein ID WP_000344800.1
Coordinates 3771226..3771600 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX30_RS18610 (3766315) 3766315..3767508 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QDX30_RS18615 (3767531) 3767531..3770680 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
QDX30_RS18620 (3771226) 3771226..3771600 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QDX30_RS18625 (3771626) 3771626..3771844 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QDX30_RS18630 (3772016) 3772016..3772567 + 552 WP_063118620.1 maltose O-acetyltransferase -
QDX30_RS18635 (3772683) 3772683..3773153 + 471 WP_063085325.1 YlaC family protein -
QDX30_RS18640 (3773317) 3773317..3774867 + 1551 WP_063085326.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QDX30_RS18645 (3774909) 3774909..3775262 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QDX30_RS18655 (3775641) 3775641..3775952 + 312 WP_000409911.1 MGMT family protein -
QDX30_RS18660 (3775983) 3775983..3776555 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T277706 WP_001291435.1 NZ_CP122685:3771626-3771844 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT277706 WP_000344800.1 NZ_CP122685:3771226-3771600 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References