Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3339319..3340024 Replicon chromosome
Accession NZ_CP122685
Organism Escherichia coli strain ETEC4067

Toxin (Protein)


Gene name relE Uniprot ID A0A3A6SJV3
Locus tag QDX30_RS16620 Protein ID WP_063085620.1
Coordinates 3339319..3339705 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag QDX30_RS16625 Protein ID WP_001280945.1
Coordinates 3339695..3340024 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX30_RS16600 (3335323) 3335323..3335949 + 627 WP_001314584.1 glutathione S-transferase GstB -
QDX30_RS16605 (3335946) 3335946..3337061 - 1116 WP_063085618.1 aldose sugar dehydrogenase YliI -
QDX30_RS16610 (3337172) 3337172..3337555 - 384 WP_000497137.1 biofilm formation regulator BssR -
QDX30_RS16615 (3337768) 3337768..3339093 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
QDX30_RS16620 (3339319) 3339319..3339705 + 387 WP_063085620.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QDX30_RS16625 (3339695) 3339695..3340024 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
QDX30_RS16630 (3340094) 3340094..3341422 - 1329 WP_000086873.1 GGDEF domain-containing protein -
QDX30_RS16635 (3341430) 3341430..3343778 - 2349 WP_021523051.1 EAL domain-containing protein -
QDX30_RS16640 (3343956) 3343956..3344867 - 912 WP_001236019.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14280.45 Da        Isoelectric Point: 9.9296

>T277705 WP_063085620.1 NZ_CP122685:3339319-3339705 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSTKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT277705 WP_001280945.1 NZ_CP122685:3339695-3340024 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A6SJV3

Antitoxin

Source ID Structure

References