Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2608361..2608999 Replicon chromosome
Accession NZ_CP122685
Organism Escherichia coli strain ETEC4067

Toxin (Protein)


Gene name hicA Uniprot ID A0A3A6S5Q3
Locus tag QDX30_RS12845 Protein ID WP_063085535.1
Coordinates 2608823..2608999 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QDX30_RS12840 Protein ID WP_001270286.1
Coordinates 2608361..2608777 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX30_RS12815 (2603409) 2603409..2603528 - 120 Protein_2508 ABC transporter permease -
QDX30_RS12820 (2603501) 2603501..2604454 - 954 WP_242378934.1 ABC transporter permease -
QDX30_RS12825 (2604455) 2604455..2605468 - 1014 WP_063085537.1 ABC transporter ATP-binding protein -
QDX30_RS12830 (2605486) 2605486..2606631 - 1146 WP_000047450.1 ABC transporter substrate-binding protein -
QDX30_RS12835 (2606876) 2606876..2608282 - 1407 WP_063085536.1 PLP-dependent aminotransferase family protein -
QDX30_RS12840 (2608361) 2608361..2608777 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QDX30_RS12845 (2608823) 2608823..2608999 - 177 WP_063085535.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QDX30_RS12850 (2609221) 2609221..2609451 + 231 WP_000494244.1 YncJ family protein -
QDX30_RS12855 (2609543) 2609543..2611504 - 1962 WP_063085534.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QDX30_RS12860 (2611577) 2611577..2612113 - 537 WP_000429507.1 DNA-binding transcriptional regulator SutR -
QDX30_RS12865 (2612205) 2612205..2613376 + 1172 Protein_2518 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6751.78 Da        Isoelectric Point: 11.5666

>T277703 WP_063085535.1 NZ_CP122685:c2608999-2608823 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFQGRRSVMPRHPNDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT277703 WP_001270286.1 NZ_CP122685:c2608777-2608361 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A6S5Q3

Antitoxin

Source ID Structure

References