Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2525768..2527356 Replicon chromosome
Accession NZ_CP122685
Organism Escherichia coli strain ETEC4067

Toxin (Protein)


Gene name hipA Uniprot ID A0A3A6RNL0
Locus tag QDX30_RS12465 Protein ID WP_063085289.1
Coordinates 2526034..2527356 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QDX30_RS12460 Protein ID WP_001296726.1
Coordinates 2525768..2526034 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX30_RS12460 (2525768) 2525768..2526034 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QDX30_RS12465 (2526034) 2526034..2527356 + 1323 WP_063085289.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
QDX30_RS12470 (2527754) 2527754..2528651 - 898 Protein_2439 LysR substrate-binding domain-containing protein -
QDX30_RS12475 (2528791) 2528791..2529099 + 309 WP_001221046.1 hypothetical protein -
QDX30_RS12480 (2529108) 2529108..2529797 + 690 WP_000801314.1 type 1 glutamine amidotransferase domain-containing protein -
QDX30_RS12485 (2529859) 2529859..2530806 + 948 WP_063085290.1 aldo/keto reductase -
QDX30_RS12490 (2530909) 2530909..2531064 + 156 WP_001327998.1 hypothetical protein -
QDX30_RS12495 (2531024) 2531024..2531443 + 420 WP_001314733.1 amidohydrolase family protein -
QDX30_RS12500 (2531433) 2531433..2531585 + 153 WP_001314732.1 amidohydrolase family protein -
QDX30_RS12505 (2531735) 2531735..2532307 + 573 WP_000789914.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49313.91 Da        Isoelectric Point: 8.5849

>T277702 WP_063085289.1 NZ_CP122685:2526034-2527356 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLANRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEQLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDHVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT277702 WP_001296726.1 NZ_CP122685:2525768-2526034 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A6RNL0

Antitoxin

Source ID Structure

References