Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3715077..3715695 Replicon chromosome
Accession NZ_CP122681
Organism Escherichia coli strain ETEC4068

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QDW67_RS18220 Protein ID WP_001291435.1
Coordinates 3715477..3715695 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QDW67_RS18215 Protein ID WP_000344800.1
Coordinates 3715077..3715451 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW67_RS18205 (3710166) 3710166..3711359 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QDW67_RS18210 (3711382) 3711382..3714531 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
QDW67_RS18215 (3715077) 3715077..3715451 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QDW67_RS18220 (3715477) 3715477..3715695 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QDW67_RS18225 (3715867) 3715867..3716418 + 552 WP_000102564.1 maltose O-acetyltransferase -
QDW67_RS18230 (3716534) 3716534..3717004 + 471 WP_063085325.1 YlaC family protein -
QDW67_RS18235 (3717168) 3717168..3718718 + 1551 WP_063085326.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QDW67_RS18240 (3718760) 3718760..3719113 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QDW67_RS18250 (3719492) 3719492..3719803 + 312 WP_000409911.1 MGMT family protein -
QDW67_RS18255 (3719834) 3719834..3720406 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T277687 WP_001291435.1 NZ_CP122681:3715477-3715695 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT277687 WP_000344800.1 NZ_CP122681:3715077-3715451 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References