Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3287258..3287963 Replicon chromosome
Accession NZ_CP122681
Organism Escherichia coli strain ETEC4068

Toxin (Protein)


Gene name relE Uniprot ID A0A3A6SJV3
Locus tag QDW67_RS16245 Protein ID WP_063085620.1
Coordinates 3287258..3287644 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag QDW67_RS16250 Protein ID WP_001280945.1
Coordinates 3287634..3287963 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW67_RS16225 (3283262) 3283262..3283888 + 627 WP_001314584.1 glutathione S-transferase GstB -
QDW67_RS16230 (3283885) 3283885..3285000 - 1116 WP_063085618.1 aldose sugar dehydrogenase YliI -
QDW67_RS16235 (3285111) 3285111..3285494 - 384 WP_000497137.1 biofilm formation regulator BssR -
QDW67_RS16240 (3285707) 3285707..3287032 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
QDW67_RS16245 (3287258) 3287258..3287644 + 387 WP_063085620.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QDW67_RS16250 (3287634) 3287634..3287963 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
QDW67_RS16255 (3288033) 3288033..3289361 - 1329 WP_000086873.1 GGDEF domain-containing protein -
QDW67_RS16260 (3289369) 3289369..3291717 - 2349 WP_021523051.1 EAL domain-containing protein -
QDW67_RS16265 (3291895) 3291895..3292806 - 912 WP_001236019.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14280.45 Da        Isoelectric Point: 9.9296

>T277686 WP_063085620.1 NZ_CP122681:3287258-3287644 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSTKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT277686 WP_001280945.1 NZ_CP122681:3287634-3287963 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A6SJV3

Antitoxin

Source ID Structure

References