Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2605294..2605932 Replicon chromosome
Accession NZ_CP122681
Organism Escherichia coli strain ETEC4068

Toxin (Protein)


Gene name hicA Uniprot ID A0A3A6S5Q3
Locus tag QDW67_RS12765 Protein ID WP_063085535.1
Coordinates 2605756..2605932 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QDW67_RS12760 Protein ID WP_001270286.1
Coordinates 2605294..2605710 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW67_RS12740 (2600446) 2600446..2601387 - 942 WP_063085538.1 ABC transporter permease -
QDW67_RS12745 (2601388) 2601388..2602401 - 1014 WP_063085537.1 ABC transporter ATP-binding protein -
QDW67_RS12750 (2602419) 2602419..2603564 - 1146 WP_000047450.1 ABC transporter substrate-binding protein -
QDW67_RS12755 (2603809) 2603809..2605215 - 1407 WP_063085536.1 PLP-dependent aminotransferase family protein -
QDW67_RS12760 (2605294) 2605294..2605710 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QDW67_RS12765 (2605756) 2605756..2605932 - 177 WP_063085535.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QDW67_RS12770 (2606154) 2606154..2606384 + 231 WP_000494244.1 YncJ family protein -
QDW67_RS12775 (2606476) 2606476..2608437 - 1962 WP_063085534.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QDW67_RS12780 (2608510) 2608510..2609046 - 537 WP_000429507.1 DNA-binding transcriptional regulator SutR -
QDW67_RS12785 (2609138) 2609138..2610309 + 1172 Protein_2502 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6751.78 Da        Isoelectric Point: 11.5666

>T277684 WP_063085535.1 NZ_CP122681:c2605932-2605756 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFQGRRSVMPRHPNDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT277684 WP_001270286.1 NZ_CP122681:c2605710-2605294 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A6S5Q3

Antitoxin

Source ID Structure

References