Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 959719..960373 Replicon chromosome
Accession NZ_CP122681
Organism Escherichia coli strain ETEC4068

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag QDW67_RS04605 Protein ID WP_000244781.1
Coordinates 959966..960373 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QDW67_RS04600 Protein ID WP_000354046.1
Coordinates 959719..959985 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW67_RS04580 (955807) 955807..957240 - 1434 WP_063085817.1 6-phospho-beta-glucosidase BglA -
QDW67_RS04585 (957285) 957285..957596 + 312 WP_001182952.1 N(4)-acetylcytidine aminohydrolase -
QDW67_RS04590 (957760) 957760..958419 + 660 WP_000250269.1 hemolysin III family protein -
QDW67_RS04595 (958496) 958496..959476 - 981 WP_000886050.1 tRNA-modifying protein YgfZ -
QDW67_RS04600 (959719) 959719..959985 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QDW67_RS04605 (959966) 959966..960373 + 408 WP_000244781.1 protein YgfX Toxin
QDW67_RS04610 (960413) 960413..960934 - 522 WP_001055888.1 flavodoxin FldB -
QDW67_RS04615 (961046) 961046..961942 + 897 WP_000806652.1 site-specific tyrosine recombinase XerD -
QDW67_RS04620 (961967) 961967..962677 + 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QDW67_RS04625 (962683) 962683..964416 + 1734 WP_000813177.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T277676 WP_000244781.1 NZ_CP122681:959966-960373 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT277676 WP_000354046.1 NZ_CP122681:959719-959985 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References