Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 723724..724559 Replicon chromosome
Accession NZ_CP122681
Organism Escherichia coli strain ETEC4068

Toxin (Protein)


Gene name yeeV Uniprot ID S1EZ92
Locus tag QDW67_RS03475 Protein ID WP_000854726.1
Coordinates 724182..724559 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag QDW67_RS03470 Protein ID WP_064559964.1
Coordinates 723724..724092 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW67_RS03435 (718901) 718901..719773 + 873 WP_096098506.1 GTPase family protein -
QDW67_RS03440 (720146) 720146..721243 + 1098 Protein_673 AIDA repeat-containing protein -
QDW67_RS03445 (721313) 721313..721654 + 342 Protein_674 DUF932 domain-containing protein -
QDW67_RS03450 (721745) 721745..722230 + 486 WP_096098508.1 antirestriction protein -
QDW67_RS03455 (722245) 722245..722721 + 477 WP_140431832.1 RadC family protein -
QDW67_RS03460 (722790) 722790..723011 + 222 WP_000692353.1 DUF987 domain-containing protein -
QDW67_RS03465 (723030) 723030..723674 + 645 WP_016240659.1 hypothetical protein -
QDW67_RS03470 (723724) 723724..724092 + 369 WP_064559964.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QDW67_RS03475 (724182) 724182..724559 + 378 WP_000854726.1 TA system toxin CbtA family protein Toxin
QDW67_RS03480 (724556) 724556..725044 + 489 WP_063080559.1 DUF5983 family protein -
QDW67_RS03485 (725056) 725056..725253 + 198 WP_063080560.1 DUF957 domain-containing protein -
QDW67_RS03490 (725338) 725338..726183 + 846 WP_049038750.1 DUF4942 domain-containing protein -
QDW67_RS03500 (726471) 726471..726977 + 507 WP_063086280.1 G/U mismatch-specific DNA glycosylase -
QDW67_RS03505 (727056) 727056..728897 - 1842 WP_000437371.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14164.10 Da        Isoelectric Point: 7.8045

>T277675 WP_000854726.1 NZ_CP122681:724182-724559 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13904.64 Da        Isoelectric Point: 5.9652

>AT277675 WP_064559964.1 NZ_CP122681:723724-724092 [Escherichia coli]
VSDTFHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRDGIRGRFRDVDAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGVTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1EZ92

Antitoxin

Source ID Structure

References