Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1168496..1168974 Replicon chromosome
Accession NC_017906
Organism Escherichia coli Xuzhou21

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag CDCO157_RS05580 Protein ID WP_001303876.1
Coordinates 1168496..1168783 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag CDCO157_RS05585 Protein ID WP_000536233.1
Coordinates 1168783..1168974 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDCO157_RS05545 1163645..1166116 - 2472 WP_000034474.1 exonuclease -
CDCO157_RS05550 1166210..1166401 - 192 WP_001098307.1 DUF1482 family protein -
CDCO157_RS30905 1166398..1166586 - 189 WP_000413705.1 cell division inhibition protein DicB -
CDCO157_RS05565 1167160..1167345 + 186 WP_001133046.1 hypothetical protein -
CDCO157_RS05570 1167532..1167921 - 390 WP_000394511.1 hypothetical protein -
CDCO157_RS05575 1168063..1168218 - 156 WP_000379575.1 DUF1391 family protein -
CDCO157_RS05580 1168496..1168783 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CDCO157_RS05585 1168783..1168974 - 192 WP_000536233.1 hypothetical protein Antitoxin
CDCO157_RS05590 1169002..1169403 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
CDCO157_RS05595 1169512..1169784 + 273 WP_000887453.1 helix-turn-helix domain-containing protein -
CDCO157_RS05600 1169768..1170193 + 426 WP_000693855.1 Rha family transcriptional regulator -
CDCO157_RS30920 1170400..1170855 - 456 WP_000273724.1 hypothetical protein -
CDCO157_RS05610 1170934..1172025 + 1092 WP_001205823.1 hypothetical protein -
CDCO157_RS05615 1172032..1172778 + 747 WP_000788751.1 ATP-binding protein -
CDCO157_RS05620 1172800..1173570 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T27767 WP_001303876.1 NC_017906:c1168783-1168496 [Escherichia coli Xuzhou21]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T27767 NC_017906:c1168783-1168496 [Escherichia coli Xuzhou21]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT27767 WP_000536233.1 NC_017906:c1168974-1168783 [Escherichia coli Xuzhou21]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT27767 NC_017906:c1168974-1168783 [Escherichia coli Xuzhou21]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References