Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4318335..4318911 Replicon chromosome
Accession NZ_CP122679
Organism Escherichia coli strain ETEC4069

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag QDW53_RS21305 Protein ID WP_001297643.1
Coordinates 4318624..4318911 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A080I7H7
Locus tag QDW53_RS21300 Protein ID WP_000063160.1
Coordinates 4318335..4318637 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW53_RS21285 (4314931) 4314931..4317081 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
QDW53_RS21290 (4317131) 4317131..4317334 + 204 WP_000467859.1 YbdD/YjiX family protein -
QDW53_RS21295 (4317345) 4317345..4318301 + 957 WP_001297640.1 GTPase -
QDW53_RS21300 (4318335) 4318335..4318637 - 303 WP_000063160.1 BrnA antitoxin family protein Antitoxin
QDW53_RS21305 (4318624) 4318624..4318911 - 288 WP_001297643.1 BrnT family toxin Toxin
QDW53_RS21310 (4319110) 4319110..4319807 - 698 Protein_4171 IS1 family transposase -
QDW53_RS21315 (4319864) 4319864..4319959 + 96 Protein_4172 dienelactone hydrolase family protein -
QDW53_RS21320 (4320105) 4320105..4321337 + 1233 WP_024186283.1 multidrug efflux MFS transporter MdtM -
QDW53_RS21325 (4321378) 4321378..4322658 + 1281 WP_001037400.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T277669 WP_001297643.1 NZ_CP122679:c4318911-4318624 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11552.01 Da        Isoelectric Point: 9.4646

>AT277669 WP_000063160.1 NZ_CP122679:c4318637-4318335 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALTNKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure
AlphaFold DB A0A080I7H7

References