Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3739959..3740577 Replicon chromosome
Accession NZ_CP122679
Organism Escherichia coli strain ETEC4069

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QDW53_RS18535 Protein ID WP_001291435.1
Coordinates 3740359..3740577 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QDW53_RS18530 Protein ID WP_000344800.1
Coordinates 3739959..3740333 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW53_RS18520 (3735048) 3735048..3736241 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QDW53_RS18525 (3736264) 3736264..3739413 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
QDW53_RS18530 (3739959) 3739959..3740333 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QDW53_RS18535 (3740359) 3740359..3740577 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QDW53_RS18540 (3740749) 3740749..3741300 + 552 WP_063118620.1 maltose O-acetyltransferase -
QDW53_RS18545 (3741416) 3741416..3741886 + 471 WP_063085325.1 YlaC family protein -
QDW53_RS18550 (3742050) 3742050..3743600 + 1551 WP_063085326.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QDW53_RS18555 (3743642) 3743642..3743995 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QDW53_RS18565 (3744374) 3744374..3744685 + 312 WP_000409911.1 MGMT family protein -
QDW53_RS18570 (3744716) 3744716..3745288 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T277666 WP_001291435.1 NZ_CP122679:3740359-3740577 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT277666 WP_000344800.1 NZ_CP122679:3739959-3740333 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References