Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3325723..3326428 Replicon chromosome
Accession NZ_CP122679
Organism Escherichia coli strain ETEC4069

Toxin (Protein)


Gene name relE Uniprot ID A0A3A6SJV3
Locus tag QDW53_RS16645 Protein ID WP_063085620.1
Coordinates 3325723..3326109 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag QDW53_RS16650 Protein ID WP_001280945.1
Coordinates 3326099..3326428 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW53_RS16625 (3321727) 3321727..3322353 + 627 WP_001314584.1 glutathione S-transferase GstB -
QDW53_RS16630 (3322350) 3322350..3323465 - 1116 WP_063085618.1 aldose sugar dehydrogenase YliI -
QDW53_RS16635 (3323576) 3323576..3323959 - 384 WP_000497137.1 biofilm formation regulator BssR -
QDW53_RS16640 (3324172) 3324172..3325497 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
QDW53_RS16645 (3325723) 3325723..3326109 + 387 WP_063085620.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QDW53_RS16650 (3326099) 3326099..3326428 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
QDW53_RS16655 (3326498) 3326498..3327826 - 1329 WP_000086873.1 GGDEF domain-containing protein -
QDW53_RS16660 (3327834) 3327834..3330182 - 2349 WP_021523051.1 EAL domain-containing protein -
QDW53_RS16665 (3330360) 3330360..3331271 - 912 WP_001236019.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14280.45 Da        Isoelectric Point: 9.9296

>T277665 WP_063085620.1 NZ_CP122679:3325723-3326109 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSTKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT277665 WP_001280945.1 NZ_CP122679:3326099-3326428 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A6SJV3

Antitoxin

Source ID Structure

References