Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2599293..2599931 Replicon chromosome
Accession NZ_CP122679
Organism Escherichia coli strain ETEC4069

Toxin (Protein)


Gene name hicA Uniprot ID A0A3A6S5Q3
Locus tag QDW53_RS12900 Protein ID WP_063085535.1
Coordinates 2599755..2599931 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QDW53_RS12895 Protein ID WP_001270286.1
Coordinates 2599293..2599709 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW53_RS12870 (2594341) 2594341..2594460 - 120 Protein_2521 ABC transporter permease -
QDW53_RS12875 (2594433) 2594433..2595386 - 954 WP_242378934.1 ABC transporter permease -
QDW53_RS12880 (2595387) 2595387..2596400 - 1014 WP_063085537.1 ABC transporter ATP-binding protein -
QDW53_RS12885 (2596418) 2596418..2597563 - 1146 WP_000047450.1 ABC transporter substrate-binding protein -
QDW53_RS12890 (2597808) 2597808..2599214 - 1407 WP_063085536.1 PLP-dependent aminotransferase family protein -
QDW53_RS12895 (2599293) 2599293..2599709 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QDW53_RS12900 (2599755) 2599755..2599931 - 177 WP_063085535.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QDW53_RS12905 (2600153) 2600153..2600383 + 231 WP_000494244.1 YncJ family protein -
QDW53_RS12910 (2600475) 2600475..2602436 - 1962 WP_063085534.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QDW53_RS12915 (2602509) 2602509..2603045 - 537 WP_000429507.1 DNA-binding transcriptional regulator SutR -
QDW53_RS12920 (2603137) 2603137..2604308 + 1172 Protein_2531 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6751.78 Da        Isoelectric Point: 11.5666

>T277663 WP_063085535.1 NZ_CP122679:c2599931-2599755 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFQGRRSVMPRHPNDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT277663 WP_001270286.1 NZ_CP122679:c2599709-2599293 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A6S5Q3

Antitoxin

Source ID Structure

References