Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2557074..2558662 Replicon chromosome
Accession NZ_CP122679
Organism Escherichia coli strain ETEC4069

Toxin (Protein)


Gene name hipA Uniprot ID A0A3A6RNL0
Locus tag QDW53_RS12675 Protein ID WP_063085289.1
Coordinates 2557340..2558662 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QDW53_RS12670 Protein ID WP_001296726.1
Coordinates 2557074..2557340 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW53_RS12670 (2557074) 2557074..2557340 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QDW53_RS12675 (2557340) 2557340..2558662 + 1323 WP_063085289.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
QDW53_RS12680 (2559060) 2559060..2559957 - 898 Protein_2483 LysR substrate-binding domain-containing protein -
QDW53_RS12685 (2560097) 2560097..2560405 + 309 WP_001221046.1 hypothetical protein -
QDW53_RS12690 (2560414) 2560414..2561103 + 690 WP_000801314.1 type 1 glutamine amidotransferase domain-containing protein -
QDW53_RS12695 (2561165) 2561165..2562112 + 948 WP_063085290.1 aldo/keto reductase -
QDW53_RS12700 (2562215) 2562215..2562370 + 156 WP_001327998.1 hypothetical protein -
QDW53_RS12705 (2562330) 2562330..2562749 + 420 WP_001314733.1 amidohydrolase family protein -
QDW53_RS12710 (2562739) 2562739..2562891 + 153 WP_001314732.1 amidohydrolase family protein -
QDW53_RS12715 (2563041) 2563041..2563613 + 573 WP_000789914.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49313.91 Da        Isoelectric Point: 8.5849

>T277662 WP_063085289.1 NZ_CP122679:2557340-2558662 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLANRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEQLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDHVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT277662 WP_001296726.1 NZ_CP122679:2557074-2557340 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A6RNL0

Antitoxin

Source ID Structure

References